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Mitch
Administrator foruma
Pridružen/-a: 11.09. 2008, 06:27
Prispevkov: 2136
Kraj: Nova Gorica
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 Objavljeno: 20 Dec 2008 11:30 Naslov sporočila: Nizki odmerek kofeina med nosečnostjo lahko zelo škodi |
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Nizki odmerek kofeina med nosečnostjo lahko poškoduje srce potomcev
Nova raziskava kaže, da če se samo dve skodelici kave zaužije med nosečnostjo je lahko dovolj, da vpliva na razvoj ploda, srce in nato zmanjša srčno funkcijo za celotno življenjsko dobo otrok. Poleg tega so raziskovalci prav tako ugotovili, da lahko tako majhna količina povzroči več telesne maščobe med moškimi, v primerjavi s tistimi, ki niso bili izpostavljeni kofeinu.
Christopher C. Wendler, Melissa Busovsky-McNeal, Satish Ghatpande, April Kalinowski, Kerry S. Russell, and Scott A. Rivkees
The purpose of this study was to determine both the short-term effects on cardiac development and embryo growth and the long-term effects on cardiac function and body composition of in utero caffeine exposure. Pregnant mice (C57BL/6) were exposed to hypoxia (10% O2) or room air from embryonic days (E) 8.5–10.5, and treated with caffeine (20 mg/kg, i.p.) or vehicle (normal saline, 0.9% NaCl). This caffeine dose results in a circulating level that is equivalent to 2 cups of coffee in humans. Hypoxic exposure acutely reduced embryonic growth by 30%. Exposure to a single dose of caffeine inhibited cardiac ventricular development by 53% in hypoxia and 37% in room air. Caffeine exposure resulted in inhibition of hypoxia-induced HIF1 protein expression in embryos by 40%. When offspring from dams treated with a single dose of caffeine were studied in adulthood, we observed that caffeine treatment alone resulted in a decrease in cardiac function of 38%, as assessed by echocardiography. We also observed a 20% increase in body fat with male mice exposed to caffeine. Caffeine was dissolved in normal saline, so it was used as a control. Room air controls were used to compare to the hypoxic mice. Exposure to a single dose of caffeine during embryogenesis results in both short-term effects on cardiac development and long-term effects on cardiac function.—Wendler, C. C., Busovsky-McNeal, M., Ghatpande, S., Kalinowski, A., Russell, K. S., Rivkees, S. A. Embryonic caffeine exposure induces adverse effects in adulthood.
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